Test for early and reliable diagnosis of endometriosis

Ziwig Endotest - World first saliva test for endometriosis

What is endometriosis?

Endometriosis is characterized by the presence of endometrial-like epithelium and/or stroma outside of the uterine cavity (womb). The growth of these tissue fragments is frequently associated with an inflammatory process1.


During menstruation, endometriosis lesions can react to variations in hormonal levels, leading to acute inflammation, bleeding, severe pain and many other symptoms. Endometriosis causes a significant deterioration in qualitý of life. Endometriosis affects about 10% of women of childbearing It potentially affects all women and can appear as early as from adolescence. Endometriosis can be completely asymptomatic and is sometimes diagnosed during a consultation prompted by difficulty in conceiving. In fact, a significant proportion of patients with endometriosis also suffer from infertility.


Symptoms of endometriosis

⚬  Severe menstrual pain

⚬  Pain during sexual intercourse

⚬  Pelvic pain outside of menstruation

⚬  Pain in the right shoulder

⚬  Digestive problems

⚬  Intense fatigue

⚬  Urinary disorders

⚬  Infertility

⚬  Pain during defecation

⚬  Painful rectal bleeding

⚬  Haematuria during menstruation

⚬  Alternating diarrhea – constipation

What is Ziwig Endotest?

Ziwig Endotest® is a simple, non-invasive diagnostic test for early detection of all forms of endometriosis with a performance that exceeds that of conventional diagnostic tests2-6 (sensitivity >95%, specificity >95%, diagnostic accuracy AUC >95%9).


Ziwig Endotest®, a test based on Next Generation sequencing of microRNAs present in saliva was developed by a French company, Ziwig.


Ziwig Endotest® has been validated by one of the largest clinical trials ever carried out in this field in collaboration with 18 French centers specialized in endometriosis9. The Diagnostic performance was tested firstly on blood samples 6, and then on saliva samples4.


This tool is set to revolutionize the diagnosis of, and the care for, endometriosis by providing a reliable and rapid diagnosis to healthcare professionals who prescribe the test.


Ziwig Endotest® has obtained the CE label.


Ziwig Endotest®  is not intended to replace diagnosis by pelvic medical imaging. Medical imaging remains essential after diagnosis for lesion description, mapping, and classification.

Why and when to prescribe the salivary test?

Compared to current methods, Ziwig Endotest® represents a major innovation in the detection of endometriosis8.


Patient care will be greatly improved via the reduction of the average time to diagnosis from several years to a few days7. Ziwig Endotest® paves the way for the early treatment of endometriosis and represents a major paradigm shift in clinical practice2.



The advantages of Ziwig Endotest®:

⚬  Clear positive/negative result

⚬  Rapid diagnosis

⚬  All forms of endometriosis can be diagnosed 2-6

⚬  High reliability: close to 100% 9

⚬  Simple and non-invasive sample collection


The prescription of Ziwig Endotest® is recommended for women between 18 and 43 years of age, presenting one or more symptoms suggestive of endometriosis 4,8.

Book Ziwig Endotest

Find clinics that offer Ziwig Endotest


Örebro, Örebro

Storgatans Gynekologiska Mottagning
Storgatan 12
703 61 Örebro

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Uppsala, Uppsala

C-Medical Fertilitet

Kålsängsgränd 10D
753 19 Uppsala

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Uppsala, Uppsala

C-Medical Gynekologi
Rundelsgränd 3C
753 12 Uppsala

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Storgatans Gynekologiska Mottagning
Storgatan 12
703 61 Örebro

Dr Izabella Jawad
072-23 04 070

Dr Claus Smed Sörensen
073-801 60 50

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Do you work in a clinic that wants to offer Ziwig Endotest?

Contact us if you are interested in offering Ziwig Endotest to your patients. We collaborate with healthcare providers and clinics across the Nordic region.